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Sun-Induced Aging

Clinical and Laboratory Observations in Man
  • W Mitchell Sams Jr.
    Correspondence
    Corresponding author: Department of Dermatology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294
    Affiliations
    Professor and Chairman, Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama
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      Chronic sun exposure can result in numerous changes in human skin, particularly the skin of fair-skinned individuals. These changes include wrinkling, elastosis, actinic keratoses, irregular pigmentation, telangiectasia, and skin cancer. Most of these alterations had formerly been considered to be caused by UVB wavelengths, which are the wavelengths probably most responsible. However, a number of recent studies have demonstrated that UVA can also cause burning, elastosis, and skin cancer. Thus, individuals exposed to intense UVB from sunlight coupled with intense UVA from suntan parlors are likely at increased risk.
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      References

        • Banfield W.G.
        • Brindley D.C.
        Preliminary observations on senile elastosis using the electron microscope.
        J. Invest. Dermatol. 1963; 41: 9-17
        • Berger H.
        • Tsamboas D.
        • Mahrle G.
        Experimental elastosis induced by chronic ultraviolet exposure.
        Arch. Dermatol. Res. 1980; 269: 39-49
        • Blum H.F.
        Carcinogenesis by Ultraviolet Light. Princeton University Press, Princeton, New Jersey1959
        • Braun-Falco O.
        Die Morphogenese der Senil-Aktinischen Elastose: Eine Elektronenmikroskopische Un-tersuchung.
        Arch. Klin. Exp. Dermatol. 1969; 235: 138-160
        • Braverman I.M.
        • Fonferko E.
        Studies in cutaneous aging: II The mircovasculature..
        J. Invest. Dermatol. 1982; 78: 444-448
        • Everett M.A.
        • Yeagers E.
        • Sayre R.M.
        • Olson R.L.
        Penetration of epidermis by ultraviolet rays. Photochem..
        Photobiol. 1966; 5: 533-542
        • Favre M.
        • Racouchot J.
        L'elasteidose cutanee nodulaire a kystes et a comedons.
        Ann. Derm. Syph. 1951; 78: 681
      1. Forbes, P.D., Davies, R.E., Coles, C.A. Photo-carcinogenesis by UVA alone [Abstract. ] Proceedings of the Tenth Annual Meeting of the American Society of Photobiology, 1982, p. 66.

        • Fullmer H.M.
        • Lillie R.D.
        The staining of collagen with elastic tissue stains.
        J. Histochem. Cyto-chem. 1957; 5: 11-14
        • Gerstein W.
        • Freeman R.G.
        Transplantation of actinically damaged skin.
        J. Invest. Dermatol. 1963; 41: 445-450
        • Gilchrest B.A.
        Relationship between actinic damage and chronologic aging in keratinocyte cultures of human skin.
        J. Invest. Dermatol. 1979; 72: 219-223
        • Gilchrest B.A.
        • Blog F.B.
        • Szabo G.
        Effects of aging and chronic sun exposure on melanocytes of human skin.
        J. Invest. Dermatol. 1979; 73: 141-143
        • Gilchrest B.A.
        • Soter N.A.
        • Hawk J.L.
        • et al.
        Histologic changes associated with ultraviolet A-induced erythema in normal human skin.
        J. Am. Acad. Dermatol. 1983; 9: 213-219
        • Gillman T.
        • Penn J.
        • Bronks D.
        • Roux M.
        Abnormal elastic fibers.
        Arch. Pathol. 1955; 59: 733-749
        • Hargis A.M.
        • Thomassen R.W.
        • Phemister R.D.
        Chronic dermatosis and cutaneous squamous-cell carcinoma in the beagle dog.
        Vet. Pathol. 1977; 14: 281-288
        • Helm F.
        Nodular cutaneous elastosis with cysts and comedones (Favre-Racouchot syndrome).
        Arch. Dermatol. 1961; 84: 666
        • Kaidbey K.H.
        • Kligman A.M.
        The acute effects of long-wave ultraviolet radiation on human skin.
        J. Invest. Dermatol. 1979; 72: 253-256
        • Kligman A.M.
        Solar elastosis in relation to pigmentation.
        in: Fitzpatrick T.B. Pathak M.A. Harber L.C. Sunlight and Man. University of Tokyo Press, Tokyo1974
        • Kligman A.M.
        Early destructive effects of sunlight on human skin.
        J.A.M.A. 1969; 210: 2377-2380
        • Kligman L.H.
        • Akin F.J.
        • Kligman A.M.
        The contributions of UVA and UVB to connective tissue damage in hairless mice.
        J. Invest. Dermatol. 1985; 84: 272-276
        • Knox J.M.
        • Cockerell E.G.
        • Freeman R.G.
        Etiological factors and premature aging.
        J.A.M.A. 1962; 179: 630-636
        • Lavker R.M.
        Structural alterations in exposed and unexposed aged skin.
        J. Invest. Dermatol. 1979; 73: 59-66
        • Lever W.F.
        Histopathology of the Skin. J.B. Lippincott Co., Philadelphia1954 (Edition 2)
        • Loewi G.
        • Glynn L.E.
        • Dorling J.
        Studies on the nature of collagen degeneration.
        J. Pathol. Bac-teriol. 1960; 80: 1-8
        • Lund H.Z.
        • Somerville R.L.
        Basophilic degeneration of the cutis: Data substantiating its relationship to prolonged solar exposure.
        Am. J. Clin. Pathol. 1957; 27: 183-190
        • Marshall D.R.
        The clinical and pathological effects of prolonged solar exposure: The association with aging of the skin. Aust.
        N.Z. J. Surg. 1965; 34: 161-172
        • Mitchell R.E.
        Chronic solar dermatosis: A light and electron microscopic study of the dermis.
        J. Invest. Dermatol. 1967; 43: 203-220
        • Nakamura K.
        • Johnson W.C.
        Ultraviolet light-induced connective tissue changes in rat skin: A histopathologic and histochemical study.
        J. Invest. Dermatol. 1968; 51: 253-258
        • Nurnberger F.
        • Schober E.
        • Ch Marsch W.
        • Dogliotti M.
        Actinic elastosis in black skin: A light-and electron microscopic study.
        Arch. Dermatol. Res. 1978; 262: 7-14
        • Parrish J.A.
        • Anderson R.R.
        • Urbach F.
        • Pitts D.
        UVA: Biological Effects of Ultraviolet Radiation with Emphasis on Human Responses to Long Wave Ultraviolet. Plenum Publishing Corp., New York1978: 7-73
        • Parrish J.A.
        • Jaenicke K.F.
        • Anderson R.R.
        Erythema and melanogenesis, action spectra of normal human skin.
        Photochem. Photobiol. 1982; 36: 187-191
        • Quevedo Jr., W.C.
        • Szabo G.
        • Virks J.
        Influence of age and UV on the population of dopa-positive melanocytes in human skin.
        J. Invest. Dermatol. 1969; 52: 287-290
        • Sams Jr., W.M.
        • Smith J.G.
        The histochemistry of chronically sun-damaged skin.
        J. Invest. Dermatol. 1961; 37: 447-453
        • Sams Jr., W.M.
        • Smith J.G.
        • Burk P.G.
        The experimental production of elastosis with ultraviolet light.
        J. Invest. Dermatol. 1964; 43: 467-471
        • Shellow W.V.
        • Kligman A.M.
        An attempt to produce elastosis in aged human skin by means of ultraviolet irradiation.
        J. Invest. Dermatol. 1968; 50: 225-226
        • Smith J.G.
        • Davidson E.A.
        • Sams Jr., W.M.
        • Clark R.D.
        Alterations in human dermal connective tissue with age and chronic sun damage.
        J. Invest. Dermatol. 1962; 39: 347-350
        • Smith J.G.
        • Davidson E.A.
        • Tindall J.P.
        • Sams Jr., W.M.
        Hexosamine and hydroxyproline alterations in chronically sun-damaged skin.
        Proc. Soc. Exp. Biol. Med. 1961; 108: 533-535
        • Unna P.G.
        The Histopathology of the Diseases of the Skin. Macmillan, New York1896
      2. van Weelden, H.de Gruijl, F.R., van der Leun, J.C. Tumors induced by UVA in mice. [Abstract.] Proceedings of the Eleventh Annual Meeting of the American Society of Photobiology, 1983, p. 579.

        • Weidman F.D.
        The pathology of the yellowing dermatoses.
        Arch. Dermatol. Syphilol. 1931; 24: 954-991