Advertisement
Review Article| Volume 41, ISSUE 1, P133-140, January 2023

Cutaneous Mesenchymal Sarcomas

  • Frances Walocko
    Affiliations
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA
    Search for articles by this author
  • Rachel E. Christensen
    Affiliations
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA
    Search for articles by this author
  • Brandon Worley
    Affiliations
    Florida Dermatology and Skin Cancer Centers, 421 Linden Lane, Lake Wales, Lake Wales, FL 33853, USA
    Search for articles by this author
  • Murad Alam
    Correspondence
    Corresponding author. Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611.
    Affiliations
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA

    Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA

    Department of Otolaryngology, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA

    Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair Street, 1600, Chicago, IL 60611, USA
    Search for articles by this author
Published:October 27, 2022DOI:https://doi.org/10.1016/j.det.2022.07.011

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Dermatologic Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Criscione V.D.
        • Weinstock M.A.
        Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002.
        J Am Acad Dermatol. 2007; 56: 968-973
        • Bogucki B.
        • Neuhaus I.
        • Hurst E.A.
        Dermatofibrosarcoma protuberans: a review of the literature.
        Dermatol Surg. 2012; 38: 537-551
        • Tolkachjov S.N.
        • Schmitt A.R.
        • Muzic J.G.
        • et al.
        Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
        Dermatol Surg. 2017; 43: 116-124
        • Bowne W.B.
        • Antonescu C.R.
        • Leung D.H.
        • et al.
        Dermatofibrosarcoma protuberans: A clinicopathologic analysis of patients treated and followed at a single institution.
        Cancer. 2000; 88: 2711-2720
        • Chang C.K.
        • Jacobs I.A.
        • Salti G.I.
        Outcomes of surgery for dermatofibrosarcoma protuberans.
        Eur J Surg Oncol. 2004; 30: 341-345
        • Gloster H.M.
        Dermatofibrosarcoma protuberans.
        J Am Acad Dermatol. 1996; 35: 355-374
        • Pedeutour F.
        • Simon M.P.
        • Minoletti F.
        • et al.
        Ring 22 chromosomes in dermatofibrosarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequences.
        Cancer Res. 1995; 55: 2400-2403
        • Hao X.
        • Billings S.D.
        • Wu F.
        • et al.
        Dermatofibrosarcoma Protuberans: Update on the Diagnosis and Treatment.
        J Clin Med. 2020; 9: 1752
        • Kim H.J.
        • Lee J.Y.
        • Kim S.H.
        • et al.
        Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34.
        Br J Dermatol. 2007; 157: 319-324
        • Liang C.A.
        • Jambusaria-Pahlajani A.
        • Karia P.S.
        • et al.
        A systematic review of outcome data for dermatofibrosarcoma protuberans with and without fibrosarcomatous change.
        J Am Acad Dermatol. 2014; 71: 781-786
        • Wrotnowski U.
        • Cooper P.H.
        • Shmookler B.M.
        Fibrosarcomatous change in dermatofibrosarcoma protuberans.
        Am J Surg Pathol. 1988; 12: 287-293
        • Miller S.J.
        • Alam M.
        • Andersen J.S.
        • et al.
        Dermatofibrosarcoma protuberans.
        J Natl Compr Canc Netw. 2012; 10: 312-318
        • National Comprehensive Cancer Network
        Dermatofibrosarcoma protuberans.
        (Available at:) (Accessed January 18, 2022)
        • Thornton S.L.
        • Reid J.
        • Papay F.A.
        • et al.
        Childhood dermatofibrosarcoma protuberans: role of preoperative imaging.
        J Am Acad Dermatol. 2005; 53: 76-83
        • Chen Y.T.
        • Tu W.T.
        • Lee W.R.
        • et al.
        The efficacy of adjuvant radiotherapy in dermatofibrosarcoma protuberans: a systemic review and meta-analysis.
        J Eur Acad Dermatol Venereol. 2016; 30: 1107-1114
        • Navarrete-Dechent C.
        • Mori S.
        • Barker C.A.
        • et al.
        Imatinib Treatment for Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans: A Systematic Review.
        JAMA Dermatol. 2019; 155: 361-369
        • Foroozan M.
        • Sei J.F.
        • Amini M.
        • et al.
        Efficacy of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: systematic review.
        Arch Dermatol. 2012; 148: 1055-1063
        • Rosenfeld D.J.
        • Cappel M.A.
        • Tolkachjov S.N.
        Cutaneous mesenchymal tumors treated with Mohs micrographic surgery: a comprehensive review.
        Int J Dermatol. 2021; 60: 1334-1342
        • Rutgers E.J.
        • Kroon B.B.
        • Albus-Lutter C.E.
        • et al.
        Dermatofibrosarcoma protuberans: treatment and prognosis.
        Eur J Surg Oncol. 1992; 18: 241-248
        • Soleymani T.
        • Aasi S.Z.
        • Novoa R.
        • et al.
        Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
        Dermatol Clin. 2019; 37: 253-259
        • Phelan P.S.
        • Rosman I.S.
        • Council M.L.
        Atypical Fibroxanthoma: The Washington University Experience.
        Dermatol Surg. 2019; 45: 1450-1458
        • de Feraudy S.
        • Mar N.
        • McCalmont T.H.
        Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma.
        Am J Surg Pathol. 2008; 32: 1111-1122
        • Hartel P.H.
        • Jackson J.
        • Ducatman B.S.
        • et al.
        CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker.
        J Cutan Pathol. 2006; 33: 24-28
        • Jibbe A.
        • Worley B.
        • Miller C.H.
        • et al.
        Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review.
        J Am Acad Dermatol. 2021; (S0190-9622(21)02519-02526)
        • Tolkachjov S.N.
        • Kelley B.F.
        • Alahdab F.
        • et al.
        Atypical fibroxanthoma: Systematic review and meta-analysis of treatment with Mohs micrographic surgery or excision.
        J Am Acad Dermatol. 2018; 79: 929-934.e6
        • Miller K.
        • Goodlad J.R.
        • Brenn T.
        Pleomorphic dermal sarcoma: adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma.
        Am J Surg Pathol. 2012; 36: 1317-1326
        • Tardío J.C.
        • Pinedo F.
        • Aramburu J.A.
        • et al.
        Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated.
        J Cutan Pathol. 2016; 43: 101-112
        • Winchester D.
        • Lehman J.
        • Tello T.
        • et al.
        Undifferentiated pleomorphic sarcoma: Factors predictive of adverse outcomes.
        J Am Acad Dermatol. 2018; 79: 853-859
        • Koch M.
        • Freundl A.J.
        • Agaimy A.
        • et al.
        Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
        Anticancer Res. 2015; 35: 5717-5735
        • Sandhu N.
        • Sauvageau A.P.
        • Groman A.
        • et al.
        Cutaneous Leiomyosarcoma: A SEER Database Analysis.
        Dermatol Surg. 2020; 46: 159-164
        • Ibanez M.A.
        • Rismiller K.
        • Knackstedt T.
        Prognostic factors, treatment, and survival in cutaneous pleomorphic sarcoma.
        J Am Acad Dermatol. 2020; 83: 388-396
        • Conic R.R.Z.
        • Damiani G.
        • Frigerio A.
        • et al.
        Incidence and outcomes of cutaneous angiosarcoma: A SEER population-based study.
        J Am Acad Dermatol. 2020; 83: 809-816
        • Guadagnolo B.A.
        • Zagars G.K.
        • Araujo D.
        • et al.
        Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp.
        Head Neck. 2011; 33: 661-667
        • Hollmig S.T.
        • Sachdev R.
        • Cockerell C.J.
        • et al.
        Spindle cell neoplasms encountered in dermatologic surgery: a review.
        Dermatol Surg. 2012; 38: 825-850
        • Wagner M.J.
        • Lyons Y.A.
        • Siedel J.H.
        • et al.
        Combined VEGFR and MAPK pathway inhibition in angiosarcoma.
        Sci Rep. 2021; 11: 9362
        • Maddox J.C.
        • Evans H.L.
        Angiosarcoma of skin and soft tissue: a study of forty-four cases.
        Cancer. 1981; 48: 1907-1921
        • Pawlik T.M.
        • Paulino A.F.
        • McGinn C.J.
        • et al.
        Cutaneous angiosarcoma of the scalp: a multidisciplinary approach.
        Cancer. 2003; 98: 1716-1726
        • Montgomery E.
        • Goldblum J.R.
        • Fisher C.
        Myofibrosarcoma: a clinicopathologic study.
        Am J Surg Pathol. 2001; 25: 219-228
        • Mentzel T.
        • Dry S.
        • Katenkamp D.
        • et al.
        Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors.
        Am J Surg Pathol. 1998; 22: 1228-1238
        • Fisher C.
        Myofibrosarcoma.
        Virchows Arch. 2004; 445: 215-223
        • Keller C.
        • Gibbs C.N.
        • Kelly S.M.
        • et al.
        Low-grade myofibrosarcoma of the head and neck: importance of surgical therapy.
        J Pediatr Hematol Oncol. 2004; 26: 119-120
        • Watanabe K.
        • Ogura G.
        • Tajino T.
        • et al.
        Myofibrosarcoma of the bone: a clinicopathologic study.
        Am J Surg Pathol. 2001; 25: 1501-1507
        • Wong G.N.
        • Webb A.
        • Gyorki D.
        • et al.
        Cutaneous leiomyosarcoma: dermal and subcutaneous.
        Australas J Dermatol. 2020; 61: 243-249
        • Rodríguez-Lomba E.
        • Molina-López I.
        • Parra-Blanco V.
        • et al.
        Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients.
        Actas dermo-sifiliograficas. 2018; 109: 140-147
        • Ciurea M.E.
        • Georgescu C v
        • Radu C.C.
        • et al.
        Cutaneous leiomyosarcoma - Case report.
        J Med Life. 2014; 7: 270-273
        • Chalfant V.
        • Schriber T.
        • Sabri A.
        • et al.
        Primary Cutaneous Leiomyosarcoma of the Lower Extremity: A Case Report and Literature Review.
        Cureus. 2021; 13: e14282
        • Soares Queirós C.
        • Filipe P.
        • Soares de Almeida L.
        Cutaneous leiomyosarcoma: a 20-year retrospective study and review of the literature.
        An Bras Dermatol. 2021; 96: 278-283
        • González-Sixto B.
        • de la Torre C.
        • Pardavila R.
        • et al.
        Leiomyosarcoma arising from scrofuloderma scar.
        Clin Exp Dermatol. 2008; 33: 776-778
        • Kaddu S.
        • Beham A.
        • Cerroni L.
        • et al.
        Cutaneous leiomyosarcoma.
        Am J Surg Pathol. 1997; 21: 979-987
        • Murphy-Chutorian B.
        • Routt E.
        • Vinelli G.
        • et al.
        A Systematic Review of the Treatment of Superficial Leiomyosarcoma With Mohs Micrographic Surgery.
        Dermatol Surg. 2019; 45: 1437-1441
        • Winchester D.S.
        • Hocker T.L.
        • Brewer J.D.
        • et al.
        Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes.
        J Am Acad Dermatol. 2014; 71: 919-925
        • Jensen M.L.
        • Jensen O.M.
        • Michalski W.
        • et al.
        Intradermal and subcutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 41 cases.
        J Cutan Pathol. 1996; 23: 458-463