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- Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system.Ann Surg Oncol. 2016; 23: 3564-3571
National Comprehensive Care Network Clinical Practice Guidelines in Oncology (NCCN Guidelines): Merkel Cell Carcinoma, Version 1.2021. 2021.
- Merkel cell carcinoma: current US incidence and projected increases based on changing demographics.J Am Acad Dermatol. 2018; 78: 457-463 e452
- Epidemiology of Merkel cell carcinoma. A population-based study from 1985 to 2013, in northeastern of France.Int J Cancer. 2019; 144: 741-745
- Incidence and survival for Merkel cell carcinoma in Queensland, Australia, 1993-2010.JAMA Dermatol. 2014; 150: 864-872
- The clinical profile of Merkel cell carcinoma in mainland China.Int J Dermatol. 2012; 51: 1054-1059
- Immunosenescence: emerging challenges for an ageing population.Immunology. 2007; 120: 435-446
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- The etiology and epidemiology of Merkel cell carcinoma.Curr Probl Cancer. 2010; 34: 14-37
- Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study.J Cutan Pathol. 2010; 37: 20-27
- Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.J Invest Dermatol. 2013; 133: 642-646
- Clonal integration of a polyomavirus in human Merkel cell carcinoma.Science. 2008; 319: 1096-1100
- Serological evidence of Merkel cell polyomavirus primary infections in childhood.J Clin Virol. 2011; 50: 125-129
- Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays.Int J Cancer. 2009; 125: 1250-1256
- How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.J Invest Dermatol. 2015; 135: 1221-1224
- Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.J Invest Dermatol. 2009; 129: 246-248
- Merkel cell polyomavirus exhibits dominant control of the tumor genome and transcriptome in virus-associated Merkel cell carcinoma.mBio. 2017; 8 (e02079–16)
- RB1 is the crucial target of the Merkel cell polyomavirus large T antigen in Merkel cell carcinoma cells.Oncotarget. 2016; 7: 32956-32968
- The distinctive mutational spectra of polyomavirus-negative Merkel cell carcinoma.Cancer Res. 2015; 75: 3720-3727
- Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.Oncotarget. 2016; 7: 3403-3415
- UV-associated mutations underlie the etiology of mcv-negative Merkel cell carcinomas.Cancer Res. 2015; 75: 5228-5234
- Immunohistochemical analyses point to epidermal origin of human Merkel cells.Histochem Cell Biol. 2014; 141: 407-421
- Neural crest origin of mammalian Merkel cells.Dev Biol. 2003; 253: 258-263
- Early B-cell differentiation in Merkel cell carcinomas: clues to cellular ancestry.Cancer Res. 2013; 73: 4982-4987
- Merkel cell carcinoma.Ann Oncol. 2010; 21: vii81-vii85
- Merkel cell polyomavirus infection and Merkel cell carcinoma.Curr Opin Virol. 2016; 2016: 20-27
- Merkel cell carcinoma update: the case for two tumours.J Eur Acad Dermatol Venereol. 2020; 34: 1425-1431
- Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the “AEIOU” features.J Am Acad Dermatol. 2008; 58: 375-381
- Merkel cell carcinoma is still an unexpected diagnosis.J Eur Acad Dermatol Venereol. 2021; 35: e883-e884
- Update on Merkel cell carcinoma.Head Neck Pathol. 2018; 12: 31-43
- Intraepidermal Merkel cell carcinoma: a case series of a rare entity with clinical follow up.J Cutan Pathol. 2017; 44: 684-691
- Merkel cell carcinoma: an update and review: pathogenesis, diagnosis, and staging.J Am Acad Dermatol. 2018; 78: 433-442
- Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites.Am J Surg Pathol. 1997; 21: 226-234
- Neurochemical markers in human cutaneous Merkel cells. An immunohistochemical investigation.Exp Dermatol. 1995; 4: 365-371
- A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin.J Cutan Pathol. 2007; 34: 918-923
- Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung.Am J Dermatopathol. 2006; 28: 99-104
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- The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging.CA Cancer J Clin. 2017; 67: 93-99
- Prognostic factors in Merkel cell carcinoma: analysis of 240 cases.J Am Acad Dermatol. 2013; 68: 425-432
- Merkel cell carcinoma: a population analysis on survival.J Natl Compr Canc Netw. 2016; 14: 1247-1257
- CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.Am J Clin Pathol. 2014; 142: 452-458
- Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.J Clin Oncol. 2011; 29: 1539-1546
- Clinical benefit of baseline imaging in Merkel cell carcinoma: analysis of 584 patients.J Am Acad Dermatol. 2021; 84: 330-339
- How we treat Merkel cell carcinoma: within and beyond current guidelines.Future Oncol. 2021; 17: 1363-1377
- Sentinel lymph node biopsy in Merkel cell carcinoma: Rates and predictors of compliance with the National Comprehensive Cancer Network guidelines.J Am Acad Dermatol. 2022; https://doi.org/10.1016/j.jaad.2022.05.054
- Merkel cell carcinoma: prognosis and treatment of patients from a single institution.J Clin Oncol. 2005; 23: 2300-2309
- Features predicting sentinel lymph node positivity in Merkel cell carcinoma.J Clin Oncol. 2011; 29: 1036-1041
- Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.J Am Acad Dermatol. 2014; 70: 637-643
- Recurrence and survival in patients undergoing sentinel lymph node biopsy for Merkel cell carcinoma: analysis of 153 patients from a single institution.Ann Surg Oncol. 2011; 18: 2529-2537
- Sentinel lymph node biopsy in Merkel cell carcinoma: predictors of sentinel lymph node positivity and association with overall survival.J Am Acad Dermatol. 2019; 81: 364-372
- Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.J Am Acad Dermatol. 2010; 63: 751-761
- Sentinel lymph node biopsy in Merkel cell carcinoma: the Mayo Clinic experience of 150 patients.Surg Oncol. 2018; 27: 11-17
- Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: the Dana-Farber experience and meta-analysis of the literature.Arch Dermatol. 2006; 142: 685-690
- Merkel cell carcinoma: updates on staging and management.Dermatol Clin. 2019; 37: 269-277
- Resection margins in Merkel cell carcinoma: is a 1-cm margin wide enough?.Ann Surg Oncol. 2018; 25: 3334-3340
- Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival.Arch Otolaryngol Head Neck Surg. 2001; 127: 149-154
- Merkel cell carcinoma: review of 22 cases with surgical, pathologic, and therapeutic considerations.Cancer. 2000; 88: 1842-1851
- Merkel cell carcinoma. Prognosis and management.Arch Surg. 1991; 126: 1514-1519
- Demographics and outcomes of stage I and II Merkel cell carcinoma treated with Mohs micrographic surgery compared with wide local excision in the National Cancer Database.J Am Acad Dermatol. 2018; 79: 126-134 e123
- Merkel cell carcinoma. Comparison of Mohs micrographic surgery and wide excision in eighty-six patients.Dermatol Surg. 1997; 23: 929-933
- Radiotherapy and conservative surgery in the locoregional management of Merkel cell carcinoma: the British Columbia Cancer Agency experience.Ann Surg Oncol. 2016; 23: 573-578
- Narrow excision margins are appropriate for Merkel cell carcinoma when combined with adjuvant radiation: Analysis of 188 cases of localized disease and proposed management algorithm.J Am Acad Dermatol. 2021; 84: 340-347
- Mohs surgery for early-stage Merkel cell carcinoma (MCC) achieves local control better than wide local excision +/- radiation therapy with no increase in MCC-specific death.Int J Dermatol. 2021; 60: 1010-1012
- Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation.J Am Acad Dermatol. 2002; 47: 885-892
- Utilization patterns and survival outcomes after wide local excision or Mohs micrographic surgery for Merkel cell carcinoma in the United States, 2004-2009.J Am Acad Dermatol. 2018; 78: 175-177 e173
- Mohs micrographic surgery versus wide local excision in the treatment of merkel cell carcinoma: a systematic review.Dermatol Surg. 2021; 48: 176-180
- Relative survival analysis in patients with stage I-II Merkel cell carcinoma treated with Mohs micrographic surgery or wide local excision.J Am Acad Dermatol. 2018; (S0190-9622(18)30816-8. Epub ahead of print)
- Outcomes of Merkel cell carcinoma treated with radiotherapy without radical surgical excision.Ann Surg Oncol. 2014; 21: 3401-3405
- Radiotherapy alone in patients with Merkel cell carcinoma: the Westmead Hospital experience of 41 patients.Australas J Dermatol. 2015; 56: 19-24
- Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908 cases from the national cancer data base.J Natl Cancer Inst. 2016; 108: djw042
- Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck.Adv Radiat Oncol. 2016; 1: 244-251
- Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin.J Clin Oncol. 2007; 25: 1043-1047
- Postoperative, single-fraction radiation therapy in Merkel cell carcinoma of the head and neck.Adv Radiat Oncol. 2020; 5: 1248-1254
- Single-fraction radiation therapy in patients with metastatic Merkel cell carcinoma.Cancer Med. 2015; 4: 1161-1170
- Negative sentinel lymph node biopsy in Merkel cell carcinoma is associated with a low risk of same-nodal-basin recurrences.Ann Surg Oncol. 2015; 22: 4060-4066
- Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma.Cancer. 2010; 116: 1783-1790
- Neoadjuvant nivolumab for patients with resectable Merkel cell carcinoma in the checkmate 358 trial.J Clin Oncol. 2020; 38: 2476-2487
- Merkel cell carcinoma: an algorithm for multidisciplinary management and decision-making.Crit Rev Oncol Hematol. 2016; 98: 170-179
- Merkel cell polyomavirus-specific CD8(+) and CD4(+) T-cell responses identified in Merkel cell carcinomas and blood.Clin Cancer Res. 2011; 17: 6671-6680
- T-cell responses to oncogenic Merkel cell polyomavirus proteins distinguish patients with Merkel cell carcinoma from healthy donors.Clin Cancer Res. 2014; 20: 1768-1778
- Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.Clin Cancer Res. 2013; 19: 5351-5360
- Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic Merkel cell carcinoma: a preplanned interim analysis of a clinical trial.JAMA Oncol. 2018; 4: e180077
- PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma.N Engl J Med. 2016; 374: 2542-2552
- Durable tumor regression and overall survival in patients with advanced Merkel cell carcinoma receiving pembrolizumab as first-line therapy.J Clin Oncol. 2019; 37: 693-702
- Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.Lancet Oncol. 2016; 17: 1374-1385
- Three-year survival, correlates and salvage therapies in patients receiving first-line pembrolizumab for advanced Merkel cell carcinoma.J Immunother Cancer. 2021; 9: e002478
- Avelumab in patients with previously treated metastatic Merkel cell carcinoma (JAVELIN Merkel 200): updated overall survival data after >5 years of follow-up.ESMO Open. 2021; 6: 100290
- Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma.Cancer Immunol Immunother. 2021; 70: 2087-2093
- Durable remission after rechallenge with ipilimumab and nivolumab in metastatic Merkel cell carcinoma refractory to avelumab: any role for sequential immunotherapy?.J Dermatol. 2021; 48: e80-e81
- Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma.Cancer Med. 2016; 5: 2294-2301
- Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma.Cancer. 1999; 85: 2589-2595
- Short-course radiation therapy for Merkel cell carcinoma: relative effectiveness in a ‘‘radiosensitive’’ tumor.Int J Radiat Oncol. 2016; 96: S160
- Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.Blood. 2009; 114: 589-595
- Intratumoral G100, a TLR4 agonist, induces antitumor immune responses and tumor regression in patients with Merkel cell carcinoma.Clin Cancer Res. 2019; 25: 1185-1195
- Intratumoral delivery of plasmid IL12 via electroporation leads to regression of injected and noninjected tumors in Merkel cell carcinoma.Clin Cancer Res. 2020; 26: 598-607
- Talimogene laherparepvec induces durable response of regionally advanced Merkel cell carcinoma in 4 consecutive patients.JAAD Case Rep. 2019; 5: 782-786
- Therapeutic targets for vaccination in polyomavirus-driven Merkel cell carcinoma.Dermatol Ther. 2022; 35: e15580
- Intersection of two checkpoints: could inhibiting the DNA damage response checkpoint rescue immune checkpoint-refractory cancer?.Cancers (Basel). 2021; 13: 3415
- Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.Proc Natl Acad Sci U S A. 2019; 116: 1027-1032
- The HDAC inhibitor domatinostat promotes cell-cycle arrest, induces apoptosis, and increases immunogenicity of Merkel cell carcinoma cells.J Invest Dermatol. 2021; 141: 903-912 e904
- Merkel cell carcinoma: critical review with guidelines for multidisciplinary management.Cancer. 2007; 110: 1-12
- Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma.Br J Dermatol. 2016; 174: 813-822
- Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: a prospective validation study.Cancer. 2017; 123: 1464-1474
- Detection and characterization of circulating tumor cells in patients with Merkel cell carcinoma.Clin Chem. 2019; 65: 462-472