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Review Article| Volume 41, ISSUE 2, P351-358, April 2023

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Racial and Ethnic Disparities in Research and Clinical Trials

Published:February 01, 2023DOI:https://doi.org/10.1016/j.det.2022.10.007

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      References

      1. America’s Racial and Ethnic Minorities. PRB.
        (Available at:) (Accessed December 14, 2021)
        • Coakley M.
        • Fadiran E.O.
        • Parrish L.J.
        • et al.
        Dialogues on diversifying clinical trials: successful strategies for engaging women and minorities in clinical trials.
        J Womens Health 2002. 2012; 21: 713-716
        • Turner B.E.
        • Steinberg J.R.
        • Weeks B.T.
        • et al.
        Race/ethnicity reporting and representation in US clinical trials: a cohort study.
        Lancet Reg Health – Am. 2022; 0https://doi.org/10.1016/j.lana.2022.100252
        • Parvanova I.
        • Finkelstein J.
        Disparities in Racial and Ethnic Representation in Stem Cell Clinical Trials.
        Importance Health Inform Public Health Pandemic. 2020; : 358-361https://doi.org/10.3233/SHTI200569
        • Khan M.S.
        • Shahid I.
        • Siddiqi T.J.
        • et al.
        Ten-year trends in enrollment of women and minorities in pivotal trials supporting recent us food and drug administration approval of novel cardiometabolic drugs.
        J Am Heart Assoc. 2020; 9https://doi.org/10.1161/JAHA.119.015594
        • Andrasik M.P.
        • Broder G.B.
        • Wallace S.E.
        • et al.
        Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
        PLoS ONE. 2021; 16: e0258858
        • Charrow A.
        • Xia F.D.
        • Joyce C.
        • et al.
        Diversity in dermatology clinical trials: a systematic review.
        JAMA Dermatol. 2017; 153: 193-198
        • Price K.N.
        • Krase J.M.
        • Loh T.Y.
        • et al.
        Racial and ethnic disparities in global atopic dermatitis clinical trials.
        Br J Dermatol. 2020; 183: 378-380
        • Niranjan S.J.
        • Martin M.Y.
        • Fouad M.N.
        • et al.
        Bias and stereotyping among research and clinical professionals: Perspectives on minority recruitment for oncology clinical trials.
        Cancer. 2020; 126: 1958-1968
        • Rochon P.A.
        • Mashari A.
        • Cohen A.
        • et al.
        The inclusion of minority groups in clinical trials: problems of under representation and under reporting of data.
        Account Res. 2004; 11: 215-223
        • Geller S.E.
        • Adams MG
        • Carnes M.
        Adherence to federal guidelines for reporting of sex and race/ethnicity in clinical trials.
        J Womens Health 2002. 2006; 15: 1123-1131
        • Luebbert R.
        • Perez A.
        Barriers to clinical research participation among African Americans.
        J Transcult Nurs. 2016; 27: 456-463
        • Sartin J.S.
        • Sims J.M.
        the father of gynecology: hero or villain?.
        South Med J. 2004; 97: 500-505
        • Holland B.
        The ‘father of modern gynecology’ performed shocking experiments on enslaved women. HISTORY.
        (Available at:) (Accessed December 10, 2021)
        • Brandt A.M.
        Racism and research: the case of the tuskegee syphilis study.
        Hastings Cent Rep. 1978; 8: 21-29
        • Sodeke S.O.
        • Powell L.R.
        Paying tribute to henrietta lacks at tuskegee university and at the virginia henrietta lacks commission, richmond, virginia.
        J Health Care Poor Underserved. 2019; 30: 1-11
        • McGehee Harvey A.
        Johns Hopkins--the birthplace of tissue culture: the story of Ross G. Harrison, Warren H. Lewis and George O. Gey.
        Johns Hopkins Med J. 1975; 136: 142-149
      2. Lasting Scars: Albert Kligman and the Holmesburg Prison Experiments.
        (Available at:) (Accessed December 7, 2021)
      3. U. involved in chemical tests on prisoners | The Daily Pennsylvanian.
        (Available at:) (Accessed April 7, 2022)
        • Owens O.L.
        • Jackson D.D.
        • Thomas T.L.
        • et al.
        African American men’s and women’s perceptions of clinical trials research: focusing on prostate cancer among a high-risk population in the South.
        J Health Care Poor Underserved. 2013; 24: 1784-1800
        • Freimuth V.S.
        • Quinn S.C.
        • Thomas S.B.
        • et al.
        African Americans’ views on research and the Tuskegee Syphilis Study.
        Soc Sci Med 1982. 2001; 52: 797-808
        • Slomka J.
        • Ratliff E.A.
        • McCurdy S.
        • et al.
        Perceptions of risk in research participation among underserved minority drug users.
        Subst Use Misuse. 2008; 43: 1640-1652
        • Brown R.F.
        • Cadet D.L.
        • Houlihan R.H.
        • et al.
        Perceptions of participation in a phase I, II, or III clinical trial among African American patients with cancer: what do refusers say?.
        J Oncol Pract. 2013; 9: 287-293
        • Shwe S.
        • Nguyen C.
        • Bhutani T.
        Racial disparities in clinical trials of biologic treatments for psoriatic arthritis.
        J Am Acad Dermatol. 2021; (S0190-9622(21)02381-1)https://doi.org/10.1016/j.jaad.2021.08.038
        • Ding J.
        • Zhou Y.
        • Khan M.S.
        • et al.
        Representation of sex, race, and ethnicity in pivotal clinical trials for dermatological drugs.
        Int J Womens Dermatol. 2021; 7: 428-434
        • Poladian K.
        • De Souza B.
        • McMichael A.J.
        Atopic dermatitis in adolescents with skin of color.
        Cutis. 2019; 104: 164-168
        • Hirano S.A.
        • Murray S.B.
        • Harvey V.M.
        Reporting, representation, and subgroup analysis of race and ethnicity in published clinical trials of atopic dermatitis in the United States between 2000 and 2009.
        Pediatr Dermatol. 2012; 29: 749-755
        • Ferguson J.E.
        • Vetos D.
        • Ho B.V.
        • et al.
        Trends in diversity of participants in dermatology clinical trials over time: a systematic review.
        J Am Acad Dermatol. 2021; (S0190-9622(21)01090-2)https://doi.org/10.1016/j.jaad.2021.05.052
        • Chen V.
        • Akhtar S.
        • Zheng C.
        • et al.
        Assessment of Changes in Diversity in Dermatology Clinical Trials Between 2010-2015 and 2015-2020: A Systematic Review.
        JAMA Dermatol. 2022; https://doi.org/10.1001/jamadermatol.2021.5596
        • Alexis A.F.
        • Sergay A.B.
        • Taylor S.C.
        Common dermatologic disorders in skin of color: a comparative practice survey.
        Cutis. 2007; 80: 387-394
        • Montgomery S.N.B.
        • Elbuluk N.
        A quantitative analysis of research publications focused on the top chief complaints in patients with skin of color.
        J Am Acad Dermatol. 2021; 85: 241-242
        • Vlassova N.
        • Kuhn D.
        • Okoye G.
        Hidradenitis suppurativa disproportionately affects African Americans: a single-center retrospective analysis.
        Acta Derm Venereol. 2015; 95: 990-991
        • Price K.N.
        • Hsiao J.L.
        • Shi V.Y.
        Race and ethnicity gaps in global hidradenitis suppurativa clinical trials.
        Dermatol Basel Switz. 2021; 237: 97-102
        • Ding J.
        • Haq A.F.
        • Joseph M.
        • et al.
        Disparities in pediatric clinical trials for acne vulgaris: A cross-sectional study.
        J Am Acad Dermatol. 2021; (S0190-9622(21)02654-2)https://doi.org/10.1016/j.jaad.2021.10.013
        • Otado J.
        • Kwagyan J.
        • Edwards D.
        • et al.
        Culturally competent strategies for recruitment and retention of African American populations into clinical trials.
        Clin Transl Sci. 2015; 8: 460-466
        • Yancey A.K.
        • Ortega A.N.
        • Kumanyika S.K.
        Effective recruitment and retention of minority research participants.
        Annu Rev Public Health. 2006; 27: 1-28
        • Kailas A.
        • Dawkins M.
        • Taylor S.C.
        Suggestions for increasing diversity in clinical trials.
        JAMA Dermatol. 2017; 153: 727
        • Taylor S.C.
        • Heath C.
        Cultural competence and unique concerns in patients with ethnic skin.
        J Drugs Dermatol JDD. 2012; 11: 460-465
        • Chalela P.
        • Suarez L.
        • Muñoz E.
        • et al.
        Promoting factors and barriers to participation in early phase clinical trials: patients perspectives.
        J Community Med Health Educ. 2014; 4: 1000281
        • Gorbatenko-Roth K.
        • Prose N.
        • Kundu R.V.
        • et al.
        Assessment of black patients’ perception of their dermatology care.
        JAMA Dermatol. 2019; 155: 1129-1134
        • Russell C.
        • Palmer J.R.
        • Adams-Campbell L.L.
        • et al.
        Follow-up of a large cohort of Black women.
        Am J Epidemiol. 2001; 154: 845-853
        • Stronks K.
        • Wieringa N.F.
        • Hardon A.
        Confronting diversity in the production of clinical evidence goes beyond merely including under-represented groups in clinical trials.
        Trials. 2013; 14: 177
        • Oh S.S.
        • Galanter J.
        • Thakur N.
        • et al.
        Diversity in clinical and biomedical research: a promise yet to be fulfilled.
        PLoS Med. 2015; 12: e1001918
        • Burchard E.G.
        • Ziv E.
        • Coyle N.
        • et al.
        The importance of race and ethnic background in biomedical research and clinical practice.
        N Engl J Med. 2003; 348: 1170-1175